SDS Volume (2015)

Volume 59. Polycyclic Aromatic Hydrocarbons: Binary Non-aqueous Systems, Part II Solutes F-Z, p None

Original Measurements

Khossaravi, D.; Connors, K. A.; J. Pharm. Sci. 1992, 81, 371-379.

Variables:

Room Temp: 298 $\pu{K}$
Solvent composition

Prepared by:

W.E. Acree, Jr.

Method/Apparatus/Procedure:

Constant temperature bath, calorimetric thermometer, and an HPLC equipped with ultraviolet detection.
Binary solvent mixtures were prepared by volume. Excess solute and solvent placed in glass ampoules and allowed to equilibrate in a constant temperature water bath for 48 hours. Aliquots of the saturated solutions were removed, filtered through a 0.22 micrometer polytetrafluoroethylene membrane filter, transferred to a volumetric flask, and diluted quantitatively to the mark. Solute concentrations were determined using reversed-phase HPLC with uv detection at 274 nm. 4-Butylbenzoic acid served as the internal standard.

Source and Purity of Materials:

1. Purified Grade, Mallinckrodt, Paris, Kentucky, USA, was used as received.
2. HPLC grade, J.T. Baker Chemical Company, Phillipsburg, New Jersey, USA, was used as a received.
3. Was purified with a Sybron/Barnstead PCS system consisting of prefilter, organic ion exchange, and microfilter (0.2 micrometer) cartridges.

Estimated Errors:

Ambient temperature: T/K: ±0.05. x₂^(s): ±0.0001 (compiler). c₁: 5% (relative error; compiler).